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Dejesusparada, N. Principal Investigator ; Crepani, E. Six extensive lineaments in the Brazilian study area are mapped and discussed according to their regional behavior and in relation to the adjacent continental margin. Among the first conclusions, correlations were found between the Sobral Pedro II Lineament and the megafaults that surround the West African craton; and the Pernambuco Lineament with the Ngaurandere Linemanet in Cameroon.
Ongoing research to complete the methodological stages includes the mapping of the West African structural framework, reconstruction of the pre-drift puzzle, and an analysis of the counterpart correlations.
Extensive research is ongoing to Neat NSE Trading System the underlying genetic patterns with the hope to improve early cancer diagnosis and treatment.
In this direction, the recent progress in next generation sequencing technologies has revolutionized the field of cancer genomics. However, one caveat of these studies remains the large amount of genetic variations identified and their interpretation.
We performed whole exome pyrosequencing of tumor as well as adjacent not affected normal colonic tissue from microsatellite stable MSS and microsatellite instable MSI colon cancer patients and identified more than 50, small nucleotide variations for each tissue.
In both CRCs, MSI and MSS, we found somatic mutations in the intracellular kinase domain of bone morphogenetic protein receptor 1A, BMPR1A, a gene where so far germline mutations are associated with juvenile polyposis syndrome, and show that the mutations functionally impair the protein function.