Konkurents — Haldusmenetlus — Komisjoni otsus rikkumise tuvastamise kohta — Otsus, mille tegemisel on vaja anda keerukaid majanduslikke või tehnilisi hinnanguid — Kohtulik kontroll — Piirid EÜ artiklid 81 ja 82 4. Konkurents — Turgu valitsev seisund — Olemasolu — Kaudsed tõendid — Ravimiettevõtja — Esimene turule siseneja — Ettevõtja rahaline võimsus EÜ artikkel 82 Konkurents — Turgu valitsev seisund — Kuritarvitamine — Farmaatsiatoodete turuleviimise lubade tühistamine — Tühistamine, mis takistab geneeriliste ravimite tootjatel kasutada lühimenetlust — Olulisi seadmeid käsitleva kohtupraktika kohaldamatus EÜ artikkel 82
Two generations of Marek's disease vaccines have shown reduced efficacy over the last half century due to evolution of the virus. Understanding where the virus is present may give insight into whether continued reductions in efficacy are likely.
We conducted a 3-yr surveillance study to assess the prevalence of Marek's disease virus on commercial poultry farms, determine the effect of various factors on virus prevalence, and Jaga valiku CRA tasu virus dynamics in broiler chicken houses over short weeks and long years timescales.
Quantitative PCR was used to assess wild-type virus detectability and concentration. Using data from dust samples with Bayesian generalized Tulumaks binaarseid voimalusi mixed effects models, we determined the factors that correlated with virus prevalence across farms.
Maximum likelihood and autocorrelation function estimation on additional dust samples were used to document and characterize virus concentrations within houses over time. Overall, wild-type virus was detectable at least once on 36 of farms at rates that varied substantially between farms.
Virus was detected in one of three broiler-breeder operations companiesfour of five broiler operations, and three of five egg layer operations. Marek's disease virus detectability differed by production type, bird age, day of the year, operation companyfarm, house, flock, and sample.
Within individual houses, virus concentration often dropped below detectable levels and reemerged later.
These data characterize Marek's disease virus dynamics, which are potentially important to the evolution of the virus.